Attenuated plasmodium sporozoite expressing MAGE-A3 induces antigen-specific CD8+ T cell response against lung cancer in mice
Identifieur interne : 000A55 ( Main/Exploration ); précédent : 000A54; suivant : 000A56Attenuated plasmodium sporozoite expressing MAGE-A3 induces antigen-specific CD8+ T cell response against lung cancer in mice
Auteurs : Dong Zhou [République populaire de Chine] ; Hong Zheng [République populaire de Chine] ; Quanxing Liu [République populaire de Chine] ; Xiao Lu [République populaire de Chine] ; Xufeng Deng [République populaire de Chine] ; Li Jiang [République populaire de Chine] ; Bing Hou [République populaire de Chine] ; Yong Fu [République populaire de Chine] ; Feng Zhu [République populaire de Chine] ; Yan Ding [République populaire de Chine] ; Wenyue Xu [République populaire de Chine] ; Jigang Dai [République populaire de Chine]Source :
- Cancer Biology & Medicine [ 2095-3941 ] ; 2019.
Abstract
Cancer vaccines that rely on tumor antigen-specific CD8+ T cell responses, are promising anti-cancer adjuvant immunotherapies. This study investigated whether genetically attenuated
We constructed GAS/MAGE-A3, a recombinant GAS engineered to express the lung cancer-specific antigen, melanoma-associated antigen 3 (MAGE-A3), and assessed its therapeutic effects against lung cancer.
Robust parasite-specific CD8αlowCD11ahigh and CD49dhighCD11ahigh CD4+ T cell responses as well as a MAGE-A3-specific CD8+ T cell response were induced in GAS/MAGE-A3-immunized mice. Adoptive transfer of GAS/MAGE-A3-induced CD8+ T cells from HLA-A2 transgenic mice into lung cancer-bearing nude mice inhibited tumor growth and prolonged survival.
These findings demonstrate that GAS/MAGE-A3 induces a strong MAGE-A3-specific CD8+ T cell response against lung cancer
Url:
DOI: 10.20892/j.issn.2095-3941.2018.0309
PubMed: 31516749
PubMed Central: 6713645
Affiliations:
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Hou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Yong" sort="Fu, Yong" uniqKey="Fu Y" first="Yong" last="Fu">Yong Fu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Wenyue" sort="Xu, Wenyue" uniqKey="Xu W" first="Wenyue" last="Xu">Wenyue Xu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Jigang" sort="Dai, Jigang" uniqKey="Dai J" first="Jigang" last="Dai">Jigang Dai</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République 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</title><author><name sortKey="Zhou, Dong" sort="Zhou, Dong" uniqKey="Zhou D" first="Dong" last="Zhou">Dong Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Hong" sort="Zheng, Hong" uniqKey="Zheng H" first="Hong" last="Zheng">Hong Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Quanxing" sort="Liu, Quanxing" uniqKey="Liu Q" first="Quanxing" last="Liu">Quanxing Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Xiao" sort="Lu, Xiao" uniqKey="Lu X" first="Xiao" last="Lu">Xiao Lu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Xufeng" sort="Deng, Xufeng" uniqKey="Deng X" first="Xufeng" last="Deng">Xufeng Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Cardiothoracic Surgery, The First People's Hospital of Zunyi, Zunyi 563000, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiothoracic Surgery, The First People's Hospital of Zunyi, Zunyi 563000</wicri:regionArea><wicri:noRegion>Zunyi 563000</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Bing" sort="Hou, Bing" uniqKey="Hou B" first="Bing" last="Hou">Bing Hou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Yong" sort="Fu, Yong" uniqKey="Fu Y" first="Yong" last="Fu">Yong Fu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Wenyue" sort="Xu, Wenyue" uniqKey="Xu W" first="Wenyue" last="Xu">Wenyue Xu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Jigang" sort="Dai, Jigang" uniqKey="Dai J" first="Jigang" last="Dai">Jigang Dai</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037</wicri:regionArea><wicri:noRegion>Chongqing 400037</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer Biology & Medicine</title><idno type="ISSN">2095-3941</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Cancer vaccines that rely on tumor antigen-specific CD8<sup>+</sup> T cell responses, are promising anti-cancer adjuvant immunotherapies. This study investigated whether genetically attenuated <italic>Plasmodium</italic> sporozoite (GAS) could be used as a novel vector to induce antigen-specific CD8<sup>+</sup> T cell responses against lung cancer.
</p></sec><sec><title>Methods</title><p>We constructed GAS/MAGE-A3, a recombinant GAS engineered to express the lung cancer-specific antigen, melanoma-associated antigen 3 (MAGE-A3), and assessed its therapeutic effects against lung cancer.</p></sec><sec><title>Results</title><p>Robust parasite-specific CD8α<sup>low</sup>CD11a<sup>high</sup> and CD49d<sup>high</sup>CD11a<sup>high</sup> CD4<sup>+</sup> T cell responses as well as a MAGE-A3-specific CD8<sup>+</sup> T cell response were induced in GAS/MAGE-A3-immunized mice. Adoptive transfer of GAS/MAGE-A3-induced CD8<sup>+</sup> T cells from HLA-A2 transgenic mice into lung cancer-bearing nude mice inhibited tumor growth and prolonged survival.
</p></sec><sec><title>Conclusions</title><p>These findings demonstrate that GAS/MAGE-A3 induces a strong MAGE-A3-specific CD8<sup>+</sup> T cell response against lung cancer <italic>in vivo</italic>, and indicate that GAS is a novel and efficacious antigen delivery vector for antitumor immunotherapy.
</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Dong" sort="Zhou, Dong" uniqKey="Zhou D" first="Dong" last="Zhou">Dong Zhou</name></noRegion><name sortKey="Dai, Jigang" sort="Dai, Jigang" uniqKey="Dai J" first="Jigang" last="Dai">Jigang Dai</name><name sortKey="Deng, Xufeng" sort="Deng, Xufeng" uniqKey="Deng X" first="Xufeng" last="Deng">Xufeng Deng</name><name sortKey="Deng, Xufeng" sort="Deng, Xufeng" uniqKey="Deng X" first="Xufeng" last="Deng">Xufeng Deng</name><name sortKey="Ding, Yan" sort="Ding, Yan" uniqKey="Ding Y" first="Yan" last="Ding">Yan Ding</name><name sortKey="Fu, Yong" sort="Fu, Yong" uniqKey="Fu Y" first="Yong" last="Fu">Yong Fu</name><name sortKey="Hou, Bing" sort="Hou, Bing" uniqKey="Hou B" first="Bing" last="Hou">Bing Hou</name><name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name><name sortKey="Liu, Quanxing" sort="Liu, Quanxing" uniqKey="Liu Q" first="Quanxing" last="Liu">Quanxing Liu</name><name sortKey="Lu, Xiao" sort="Lu, Xiao" uniqKey="Lu X" first="Xiao" last="Lu">Xiao Lu</name><name sortKey="Xu, Wenyue" sort="Xu, Wenyue" uniqKey="Xu W" first="Wenyue" last="Xu">Wenyue Xu</name><name sortKey="Zheng, Hong" sort="Zheng, Hong" uniqKey="Zheng H" first="Hong" last="Zheng">Hong Zheng</name><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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